← All case studies Health · biotech · clinical trials

Helix Bio cut trial analysis from weeks to hours.

Scientists were reconciling trial, lab and wearable data by hand — weeks per readout. The loom wove the threads on-prem and flagged a safety signal eleven days before the manual review would have.

0%
analysis time
0
earlier signal
0
more hypotheses
0
audit lineage
The challenge

The signal was in the data. The data was in five silos.

Helix Bio's Phase II readouts depended on four systems that never spoke: electronic data capture for case reports, a lab information system for assays, a stream of wearable-sensor data, and a separate safety database. Reconciling them was a manual, spreadsheet-stitched ritual that took two to three weeks per analysis — and every step had to be auditable for the regulator.

"By the time we had a clean view, the question had often moved on," said Dr. Adèle Fontaine, Head of Data Science. "We were data-rich and insight-poor."

The weave

An on-prem loom, inside their walls.

Because the data was sensitive, Helix ran the loom entirely within their own environment — no record ever left the building. Five threads, full lineage on every weave, validated for GxP.

EDC · case reports LIMS · lab assays Wearables · sensors Safety DB · AEs Sites · Sheets
On-prem Loom
Validated tapestry
What surfaced

Two patterns and a knot that mattered.

Knot tied · safety
An adverse-event signal, 11 days early. The loom clustered an elevated liver-enzyme pattern in a single dosing cohort and tied a knot — eleven days before the scheduled manual safety review surfaced it.
Pattern · 93% confidence
Assay drift at one lab site. A delayed biomarker response in cohort B traced not to the drug but to calibration drift at a single contract lab — visible only once LIMS and EDC threads were woven.
Pattern · 89% confidence
Wearables led self-report by six days. Sensor-derived activity dips preceded patient-reported fatigue by roughly a week, opening an earlier, objective endpoint.

The loom found a safety signal before we did. In our world, eleven days is everything.

The result

Hours, not weeks — with the paper trail intact.

What took three weeks now takes an afternoon, and every figure carries its lineage automatically, ready for the regulator. Freed from reconciliation, the science team now explores roughly four times as many hypotheses per readout — and the earlier the loom catches a signal, the safer the trial.

"We didn't replace our scientists," Fontaine said. "We gave them back the weeks they were spending on glue."

Read your own cloth.

Weave a free sample and see your first pattern in minutes.